Progesterone Tablets

Mechanism

Progesterone binds to progesterone receptors in target tissues, converting the proliferative endometrium into a secretory state, supporting implantation and maintaining pregnancy. The sustained release formulation provides prolonged hormone levels for continuous action.

Side Effects

• Drowsiness
• Dizziness
• Bloating
• Breast tenderness
• Headache

Contraindication

• Hypersensitivity to progesterone or excipients
• Undiagnosed vaginal bleeding
• Severe hepatic dysfunction
• Known/suspected breast or genital malignancy
• Avoid in undiagnosed vaginal bleeding

Interaction

• CYP3A4 Inhibitors (↑ Progesterone levels): Ketoconazole, Itraconazole (antifungals) Clarithromycin (antibiotic)
• CYP3A4 Inducers (↓ Progesterone levels): Rifampin (antibiotic for TB) Carbamazepine, Phenytoin (antiepileptics) St. John’s Wort (herbal antidepressant)
• Anticoagulants Warfarin
• Hormonal Therapies : Mifepristone and Estrogens
• Other Moderate Interactions Lamotrigine → altered metabolism, reduced seizure control.
• Levothyroxine → possible thyroid function interference.
• Alcohol → additive dizziness, drowsiness

Warning and Precautions

• Use cautiously in liver disease
• Monitor in cardiovascular conditions
• Avoid in unexplained vaginal bleeding
• Consult doctor during pregnancy

Dosage

As directed by the Physician.